Despite the rising number of deaths of his colleagues from the specially-assembled Search Block and multiple bounties on his head former DEA chief in Colombia Joe Toft resolves to not be intimidated and to continue the hunt for Escobar.

Pablo Escobar was able to rise so quickly in the cocaine business because he was willing to do anything to succeed, including threatening judges and killing policemen.

El Chapo Guzman was able to escape from prison in Mexico after his first arrest, by bribing prison officials and being carted out in a laundry basket. Once out, sought revenge through mass killings.

As agents pursue him Joaquin Guzman, or "El Chapo" reaps a fortune for himself as head of the Sinaloa cartel by producing and distributing crystal meth.

In order to get to the elusive El Chapo agents determine that the best way to go about it is to monitor all of those he associates with and to move in on his bodyguards.

Carlos Lehder and Pablo Escobar come together to destroy kidnappers and ultimately decide to join forces to build a massive drug cartel.

The DEA goes on a manhunt for Rafael Caro Quintero a member of Felix Gallardo's cartel accused of kidnapping a teenage girl.

Griselda Blanco's cocaine distribution operation in the US became so lucrative by the mid-1970s that Pablo Escobar muscled in, triggering a deadly rivalry.

After extensive efforts to turn some of Whitey Bulger's associates into informants, the Massachusetts State Police are ready to make their move, but get unexpected interference from the FBI.

After the torture and brutal murder of one of their agents, the DEA intensifies its international hunt for drug lord Juan Matta-Ballesteros.

After moving to New York City from his native North Carolina Frank Lucas very quickly moved up the criminal ladder and became the protege of notorious Harlem mob leader Bumpy Johnson

In an attempt to determine who was purchasing weapons for the Colombian paramilitary and drug trafficking group AUC, the FBI try a variety of methods of infiltration.

In an attempt to lure arms dealer Viktor Bout out of Russia DEA agents concoct a plan that appeals to the Russian's immense greed.

Host Geoff Edgers meets a private collector who shows him some amazing artifacts that came off the German submarine U-505, which was captured by the Americans at the end of WWII, including a trophy pistol that has been missing for 75 years.

Geoff takes a visit to the NSA National Cryptologic Museum to study a revolutionary new idea from the Civil War that changed battlefield tactics forever.

At the National Museum of the Marine Corps Geoff discovers an award given to a small group of heroes who filmed a crack Marine fighting crew amidst a bloody Pacific battle. The award was an Oscar for footage shot at Tarawa.